IL13RA1 and persistent truncus arteriosus: Pressure overload exposes the myocardium to significant stress, which is characterized by cardiomyocyte hypertrophy, fibrosis, apoptosis, and adverse LV remodeling.28 To simulate the effect of pressure overload, we induced TAC in 10‐week‐old female Il13ra1‐deficient and WT mice (Figure 5H).