NFE2L2 and cancer: In the effort to increase the efficacy of experimental oncolytic virotherapies, we and others have explored strategies to potentiate viral oncolysis in resistant cancer cells by combining OVs with small molecules that enhance virus replication and cell killing.7, 8, 9, 10, 11, 12, 13, 14 In the present study, we demonstrate that the restriction to VSVΔ51 oncolysis can be overcome by manipulation of the oxidative stress response using the antioxidant compound SFN as an inducer of Nrf2 antioxidant activity.