PRNP and prion disease: PrPSc, which also binds to PrPC (Solforosi et al., 2007), might act in a similar fashion, although the fact that mice expressing N-terminally truncated PrPC remain susceptible to prion diseases (Supattapone et al., 2001; Turnbaugh et al., 2012) argues against this as the primary pathogenic mechanism in these disorders.