Based on our present study, sAxl has an excellent diagnostic accuracy for the detection of advanced fibrosis/cirrhosis (AUC 0.918) and HCC at all stages (AUC 0.929) superior to AFP as well as has a favourable accuracy in HCC without cirrhosis (AUC 0.789) (Table 3). The gene discussed is AFP; the disease is hepatocellular carcinoma.