We tested a total of 233 unique samples with previously confirmed variants in 22 cancer predisposition genes: 94 samples were positive for SNVs, 95 samples for indels and 44 samples for germline CNVs (large deletions and duplications), with the majority (168 out of 228, 74%) positive for germline variants in BRCA1, BRCA2, MSH2, MLH1 and APC. (A detailed listing of samples tested per gene can be found in Table 1). Here, BRCA1 is linked to cancer.