We tested a total of 233 unique samples with previously confirmed variants in 22 cancer predisposition genes: 94 samples were positive for SNVs, 95 samples for indels and 44 samples for germline CNVs (large deletions and duplications), with the majority (168 out of 228, 74%) positive for germline variants in BRCA1, BRCA2, MSH2, MLH1 and APC. (A detailed listing of samples tested per gene can be found in Table 1). The gene discussed is APC; the disease is cancer.