Although, increased HR was observed after 6 and 48 h of GLP-1 infusion in HF patients (with and without T2DM) [42, 43] and in a meta-analysis of 32 trials comparing GLP-1RA with placebo or active comparators, although mean HR increase was less than 2 bpm [38]. Here, GCG is linked to type 2 diabetes mellitus.