Thus, after the introduction of new P2Y12 agents, the influence of Prasugrel or Ticagrelor on platelet reactivity in T2DM patients was object of studies demonstrating that Ticagrelor treated patients have overall lower platelet reactivity than patients on Prasugrel, independently of T2DM status or insulin treatment [27]. The gene discussed is INS; the disease is type 2 diabetes mellitus.