Additionally CP infects alveolar macrophages and lung monocytes leading to enhanced production of TNF-α, IL-1β, IL-6 and IL-8; infects human bronchial smooth muscle cells to produce IL-6 and basic fibroblast growth factor (with potential effects on bronchial hyper reactivity and lung remodeling that have yet to be thoroughly investigated); and chronic infection exposes tissues to chlamydial heat shock protein 60 (cHSP60) and bacterial lipopolysaccharide (LPS) that have been associated with increased inflammation and asthma (reviewed in [48]). The gene discussed is CXCL8; the disease is asthma.