For instance, the BRCA1 R1699Q missense variant is considered a VUS in the Breast Cancer Information Core (BIC) database but a pathogenic mutation in Online Mendelian Inheritance in Man and the published literature [13, 14], and pathogenic and likely pathogenic in ClinVar (entries RCV000031217, RCV000048790, RCV000131564, RCV000195350). Here, BRCA1 is linked to breast cancer.