To assess whether sestrin 2 overexpression-mediated AMPK activation influences proliferation and apoptosis, control and sestrin 2-transduced SW620 and LoVo CRC cells were treated with compound C (6-[4-(2-Piperidin-1-ylethoxy) phenyl]-3-pyridin-4-ylpyrazolo[1,5-a] pyrimidine), an inhibitor of AMPK. This evidence concerns the gene SESN2 and colorectal carcinoma.