GADD45B and breast cancer: Micro-array analysis of MCF-7 cells treated with CMCAAT revealed several AP-1 transcriptional targets of which the upregulated gene ETS2 (ETS proto-oncogene 2; 2.5-fold) and the downregulated genes RGS2 (regulator of G-protein signaling 2; 14.8-fold), EMP1 (epithelial membrane protein 1; 6.5-fold), DUSP2 (dual specificity phosphatase 2; 3.4-fold) and GADD45B (growth arrest and DNA damage inducible beta; 2.8-fold) are linked with a pro-proliferative signature in breast cancer [18–22] (Figure 3B).