SULF1 and pancreatic neoplasm: SULF1 mRNA levels in pancreatic cancer samples have been reported as increased compared with normal tissuein these patients, although SULFs were shown to attenuate other pro-tumorigenic signaling pathways and subsequently interfere with cancer advancement, e.g., inhibition of angiogenesis and tumorigenesis by SULF1 in vivo [32–33].