SULF1 and metastatic malignant neoplasm in the lymph nodes: The tumors were dichotomized into those with low and high SULF1 expression, as demonstrated in Figure 3C–3E, Table 2, high SULF1 expression was significantly associated with age less than 65 (UBUC, P = 0.015), more advanced primary tumor pT stage (P < 0.001, both UTUC and UBUC), lymph node metastasis (UTUC, P = 0.002; UBUC, P < 0.001), higher histological grade (UTUC, P = 0.019; UBUC, P = 0.007) and vascular invasion (P < 0.001, both UTUC and UBUC) in urothelial carcinomas.