IL4 and asthma: This study at first demonstrated that the transplantation of TCs could improve allergen‐induced asthma by obviously inhibiting airway inflammation and airway hyper‐responsiveness preclinically, with the down‐regulation of Th2‐related cytokine IL‐4, transcription factor GATA‐3 and Th2 cell differentiation, while up‐regulation of Th1‐related cytokine IFN‐γ, transcription factor T‐bet and Th1 cells proliferation in asthma, just like MSCs.