Previously, we performed genome-wide DNA methylation profiling using CpG methylation microarrays to examine the alterations in DNA methylation between metastatic tissues from ovarian cancer xenograft mice and ovarian carcinoma cells.5, 6, 7 Using these data, we identified two CpG sites within the GABRP promoter region that were clearly hypomethylated in all tested metastatic tissues compared with those of the ovarian carcinoma cells. The gene discussed is GABRP; the disease is ovarian carcinoma.