To address the mechanism of GABRP overexpression in metastatic ovarian cancer cells, we analyzed genome-wide DNA methylation profiling data and identified two GABRP promoter CpG sites at −1142 and −963 bp from the transcription start site that were hypomethylated in metastatic tissues from xenograft mice compared with those in the injected ovarian carcinoma cells. Here, GABRP is linked to ovarian cancer.