It was hypothesized that calcium intake could reduce the risk of cancer by promoting the activation of transcription factors CREB (cAMP response element binding protein) [35] and oncogenic Ras [36], downregulating the synthesis of 1,25-dihydroxyvitamin D [37], inducing cell cycle arrest, and promoting cell differentiation and tumor cell apoptosis. This evidence concerns the gene CREB1 and neoplasm.