Consistently, GP supplementation reduced the protein expression of ATF-6 (Figure 5A) and mRNA expression of its downstream target genes Grp78, CHOP (Figure 5B), Edem1, and Xbp1 in the HFD-fed DSS-colitis mice (Figure 5C), showing the suppression of ER stress. This evidence concerns the gene HSPA5 and colitis.