When MCF‐7 and SKBR3 cells were treated with IGF2, the cell apoptosis rates decreased compared with the cells with paclitaxel treatment, which suggested that IGF2 could protect breast cancer cell from apoptosis induced by paclitaxel MCF‐7 and SKBR3 cells (Fig. 4E and F). The gene discussed is IGF2; the disease is breast cancer.