Ether lipids have also been identified as potential endogenous ligands of peroxisome proliferator-activated receptor gamma (PPARγ) (Davies et al., 2001; McIntyre et al., 2003; Zhang et al., 2004; Tsukahara et al., 2006), a nuclear receptor critical for adipose tissue development and lipid metabolism, which is the target of the glitazone family of diabetes drugs. Here, PPARG is linked to diabetes mellitus.