K67 (N-[2-acetonyl-4-(4-ethoxybenzenesulfonylamino)naphthalene-1-yl]-4-ethoxybenzenesulfonamide) is an inhibitor of the phosphorylated p62–KEAP1 interaction that reduces the NRF2 level in HCC (67). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.