TET2 and cancer: In contrast, the TET2 and WBSCR17 L1s may be private mutations because they were found in one individual and were not found among the L1s in the phase 3 data set of the 1000 genomes project (Sudmant et al., 2015).These data, suggesting rare germline L1 variants (SYBU) or potentially private L1s (TET2 and WBSCR17), are consistent with the hypothesis that polymorphic germline or early developmental de novo somatic L1s might be risk factors predisposing an individual to developing CA.