Numerous studies demonstrate that WWOX gene is a tumor suppressor gene in various types of malignancies and either loss or reduction of the WWOX expression were found in variety of tumors.14 We found there was significant correlation between the expression of WWOX and lymphatic metastasis, hepatic metastases, differentiation, invasion depth and UICC stage, and the results are consistent with the previous studies,14,15 indicating WWOX is an important biomarker in predicting prognosis of colorectal cancer. Here, WWOX is linked to colorectal cancer.