In patients with CKD, abnormal cellular interleukin production occurs which causes sleepiness however HD causes sleeping problems by excretion of this sleep-inducing substance.3 Circadian rhythm deteriorates in HD patients because melatonin secretion, which plays the crucial role in biological clock and circadian sleep-wake rhythms and in the onset of the sleep in evenings, decreases when the kidney functions decline. This evidence concerns the gene CLOCK and Huntington disease.