These channels are an important mediators of ischemic pre-conditioning that is a powerful protector against ischemia reperfusion injury, MI and apoptosis.18,19 Insulin plays a key role in the regulation of K-ATP channels by increasing the open state probability and by decreasing their sensitivity to ATP.20 Moreover GIK infusion also reported to have vasodilator and inotropic properties.15,21. Here, INS is linked to ischemia.