EDN1 and pulmonary arterial hypertension: It improves and recovers endothelial cell function by lowering the transcription rate of ET-1, inhibiting vasoconstriction, reduce the expression of vascular endothelial cell growth factor, block the generation of reactive oxygen molecules, and controlling the mitosis and proliferation of vascular endothelial cells, thus to effectively reduce pulmonary arterial hypertension.13,14