It is possible to acquire relatively shorter and more stable cycles of latency-relapse after anti-TB treatment or immunization using more susceptible strains such as C3HeB/FeJ, and TNF-α or IFN-γ-knockout mice (Turner and Orme, 2004; Calderon et al., 2013; Henao-Tamayo et al., 2015; Olleros et al., 2015; Reeme and Robinson, 2016) or other sensitive strains screened from collaborative cross (CC) mice (Rogala et al., 2014; Elbahesh and Schughart, 2016). This evidence concerns the gene IFNG and tuberculosis.