TARDBP and amyotrophic lateral sclerosis: Of note, because not all stress models show SG formation (Takahashi et al., 2013) and SG formation may be protective for cells (Anderson and Kedersha, 2008), whether the formation of TDP-43 inclusion is detrimental remains unknown (Baloh, 2011; Cragnaz et al., 2014), and the detailed function and regulation of SGs in ALS requires continued investigation.