FUS and amyotrophic lateral sclerosis: Many ALS genes (e.g., TDP-43, FUS/TLS, hnRNPA1, MATR3) encode RNA-binding proteins that have been found to affect multiple levels of RNA processing, including mRNA transcription, RNA transport, mRNA stabilization and miRNA biogenesis (Ling et al., 2013; Taylor et al., 2016).