FUS and amyotrophic lateral sclerosis: Like TDP-43, FUS/TLS also binds to several mRNAs of ALS-related genes (including VCP, VAPB, ubiquilin-2 and OPTN, Hoell et al., 2011; Colombrita et al., 2012; Lagier-Tourenne et al., 2012) and further modulates their expression.