TARDBP and amyotrophic lateral sclerosis: Given that mitochondrial defects have been implicated in ALS and AMPK activation in studies during the past two decades (Dupuis et al., 2004a; Duffy et al., 2011; Watanabe et al., 2016), further investigations into the role of AMPK and its downstream pathways involved in the mislocalization of TDP-43 and RNA homeostasis would pave the way for a better understanding of the initiation of sporadic ALS.