KCNC4 and early-onset autosomal dominant Alzheimer disease: Kv3.4 and its accessory protein MinK-Related Peptide 2 (MIRP2) are involved in neuronal cell death induced by neurotoxic amyloid β-peptide, which is generated from amyloid precursor protein and whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer’s disease patients14.