High survivin expression combined with PD-L1 positivity was significantly associated with a high risk of death for ccRCC patients in both univariate (risk ratio, 12.82; 95% CI, 7.50–21.92; P < 0.001) and multivariate (risk ratio, 2.81; 95% CI, 1.56–5.04; P < 0.001) analyses. The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.