LRP1B and chronic obstructive pulmonary disease: As shown in Fig. 2, Fisher’s exact test analysis revealed that among the frequently mutated genes, mutations in EGFR were more enriched in non-COPD patients (25.0% in COPD Vs 39.6% in non-COPD, p = 0.047), while mutations in LRP1B were more frequently observed in COPD (31.7% in COPD Vs 13.7% in non-COPD, p = 0.003).