However, we observed a significant reduction in the expression of GABA-related presynaptic proteins, GAD65 and VGAT, in both 3xTg-AD and 3xTg-AD-dnPAK groups when compared with NonTg mice, whereas specific markers of glutamatergic synapses (PSD95, GluN2B and Synaptophysin) and postsynaptic markers of GABAergic synapses (Gephyrin, GABAA receptor) remained unchanged (Fig. 4C). Here, DLG4 is linked to Alzheimer disease.