In contrast, expression of genes encoding Cxcl2 (MIP-2α), Cxcl5 (LIX), Il1b (IL-1β) and Il6 (IL-6) was increased in the heart after MI and further increased in hearts from Hsd11b1−/− mice compared to WT mice (Fig. 3C). The gene discussed is IL1B; the disease is myocardial infarction.