In addition, as it is recognised that girls with TS are at an increased risk of dyslipidaemia, heart problems (including arrhythmia, hypertension atherosclerosis and aortic dilatation) and have impaired nonverbal skills compared with normal girls (29), the impact of GH therapy on glucose metabolism, cardiovascular abnormalities and cognitive function warrants further investigation. This evidence concerns the gene GH1 and Timothy syndrome.