These features might be detecting textural patterns caused by surrounding stromal response or the presence of TILs at the tumor periphery, a predictor of pCR in both HER2+ [54, 55] and TN [54, 56] breast cancers, because Laws features have previously been shown to enable quantification of TILs in other imaging domains [57]. The gene discussed is ERBB2; the disease is neoplasm.