Anemia was significantly more common in the post-treatment hypoalbuminemia group than in the post-treatment normal serum albumin level group (29.6% vs. 11.0%, P = 0.002), whereas the proportions of hand-foot syndrome, diarrhea, nausea, fatigue, hypertension, thrombocytopenia, leukocytopenia, alopecia, elevation of alanine aminotransferase, and hypothyroidism showed no significant differences between two groups (Table 8). This evidence concerns the gene GPT and Hand-foot syndrome.