Anemia was significantly more common in the post-treatment hypoalbuminemia group than in the post-treatment normal serum albumin level group (29.6% vs. 11.0%, P = 0.002), whereas the proportions of hand-foot syndrome, diarrhea, nausea, fatigue, hypertension, thrombocytopenia, leukocytopenia, alopecia, elevation of alanine aminotransferase, and hypothyroidism showed no significant differences between two groups (Table 8). The gene discussed is ALB; the disease is Hand-foot syndrome.