GRIK1 and Anxiety: More importantly, the GluK1 activation in the basolateral amygdala reduced the output to the central amygdala, which may explain the increased anxiety phenotype in the GluK1 knockout mice [6] In addition, the regulation of excitatory glutamate transmission by KA receptors have been also reported in the amygdala [30, 31], and such regulation is also mixed (inhibition and facilitation).