We have previously shown that tauopathy in rTg4510 mice results from a more or less simultaneous repertoire of events, including conversion of tau from a soluble 55 kDa species to an insoluble 64 kDa species, multiple post-translational modifications (e.g. phosphorylation, acetylation, nitration, ubiquitination), impaired proteostasis, aggregation and NFT formation [13]. Here, MAPT is linked to tauopathy.