MITF and melanoma: The development and progression of melanoma have beenattributed to independent or combined genetic and epigenetic eventsinvolving the RAS/RAF/MAPK, JNK, PI3K/Akt and Jak/STAT signaling pathways.Microphthalmia-associated transcription factor (MITF), the lineagedeterminant that drives expression of melanocyte-specific genes, is alsoimplicated in melanocyte transformation [82,83].