SMARCA4 and neoplasm: Knockdown of BRG1 in mammary epithelial cells slowed the rate ofproliferation [59], instead of inducingmore aggressive characteristics of a cell type that had lost a tumor suppressor.Knockdown of BRG1 in breast cancer cells similarly resulted in a reduction inthe rate of proliferation in culture [60,61] and in orthotopicxenografts [61].