In another study, knockout of Brg1in a sonic hedgehog-type medulloblastoma mouse model markedly attenuatedtumor formation and progression [95].Global gene expression studies revealed that Brg1 functioned as acoregulator for key transcription factors, including Gli1, Atoh1 and REST,to control Shh-type medulloblastoma growth. The gene discussed is GLI1; the disease is medulloblastoma.