Intriguingly, in mouse models of EGFR (L858R/T790M/C797S) driven lung cancer, a new compound that targets selected drug-resistant EGFR but spares the wild-type receptor is effective in combination with cetuximab, an antibody that blocks EGFR dimerization and thus keeps the receptor in its inactive form [8]. The gene discussed is EGFR; the disease is lung cancer.