TNNI3 and hypertrophic cardiomyopathy: Amongst the downregulated genes were two cardiac sarcomeric proteins: (1) a ventricular isoform of myosin heavy chain (MYH7B) specifically expressed in heart and linked with hypertrophic cardiomyopathy and left ventricular non-compaction and (2) Troponin I 3 (TNNI3) expressed exclusively in cardiac muscle and already linked with both dilated cardiomyopathy and familial restrictive cardiomyopathy.