This was also associated with a modest increase in the frequencies of IL-17- and IFN-γ-producing T cells in the colon of IEC-MyDON mice (Fig 5E), together suggesting that IEC-restricted functional MyD88 expression, although it does not rescue the local ILC3 response upon infection, still allows for a partial induction of inflammatory host responses in the colon. Here, MYD88 is linked to infection.