MYD88 and infection: Using this novel approach, we demonstrate that functional MyD88 in CD11c+ MNP is sufficient to activate ILC3 and to protect mice during the early phase of infection with C. rodentium. MyD88 signaling in CD11c+ MNP activated the expression of proinflammatory cytokines in colonic DC, including IL-6, IL-1β and IL-23, which resulted in a restoration of the Th17/Th1 cell response.