We first confirmed functional reactivation of the MyD88 locus in colonic MNP by assessing the RNA expression levels of MyD88 in DC (CD64−MHC-II+CD26+CD11c+) and MO (CD64+F4/80+MHC-II+), sorted from the colonic lamina propria (cLP) of the different transgenic mouse lines on day 4 after oral infection with C. rodentium. While Myd88 expression was at the detection limit in DC and MO derived from the colon of MyDOFF mice, it was expressed at WT levels in MO from both CD11c-MyDON and LysM-MyDON mice (Fig 1B). The gene discussed is DPP4; the disease is infection.