IEC-restricted MyD88 expression in IEC-MyDON mice however led to a significant decrease in FITC-dextran serum levels, revealing an important IEC-intrinsic role of MyD88 in controlling epithelial integrity upon infection with C. rodentium. Taken together, our data highlight the critical importance of MyD88-dependent signaling in CD11c+ DC and IEC for protection against intestinal bacterial infection. Here, ITGAX is linked to bacterial infectious disease.