Moreover, although we showed here that Rorc-Cre-mediated MyD88-reactivation in T cells is not sufficient to induce a substantial colonic T cell response upon infection with C. rodentium, it is still possible that reactivation of MyD88 in a subset of activated T cells in CD11c-MyDON mice additionally contributes to the development of the colonic T cell response, consistent with reports demonstrating that T cell-intrinsic IL-1R/MyD88-dependent signaling promotes the induction, survival and proliferation of Th17 cells [39, 40, 72]. The gene discussed is IL1R1; the disease is infection.