For KLH-specific IGHM, only 4 different IGHV genes were detected (IGHV2S2, IGHV2S3, IGHV2S4, or IGHV4S1); likewise for influenza-specific IGHM, 4 IGHV genes were detected (IGHV2S2, IGHV2S3, IGHV2S4, or IGHV4S2). The gene discussed is IGHM; the disease is influenza.