Moreover, we verified AMOT, PLEKHH3, ADAR, BIRC3, and LGALS3 protein over-expressions in the treatment-naïve OSA patients, and discovered a correlation between AMOT/BIRC3/LGALS3 protein expression and the presence of EDS/hypertension/CKD, respectively. This evidence concerns the gene PLEKHH3 and Ehlers-Danlos syndrome.