Previous studies showed that OE of a phospho-mimetic form of Numb (Numb-TS4D) caused ectopic NB formation and tumorous brain growth, an effect likely reflecting a dominant-negative effect of Numb-TS4D in inhibiting endogenous Numb, as co-expression of Numb-WT completely rescued the Numb-TS4D effect [27]. Here, NUMB is linked to neuroblastoma.