The analysis of a subset of genes with strong associations to neurological disease, including PD genes Parkin, ubiquitin carboxy-terminal hydrolase L1 (UCHL1), Pink-1, and protein deglycase DJ-1 (DJ-1), uniformly exhibited aging-related changes in expression in a direction consistent with promotion of disease (32 of 33 genes studied). This evidence concerns the gene PARK7 and nervous system disorder.