Given that ~9% of all patients with PCD have disease-causing variants in DNAI1 and the IVS1+2_3insT variant is estimated to account for ~57% of variant alleles in DNAI1,22 we can take these values as estimates of the maximum genetic and allelic contribution for PCD, yielding a maximum expected population AF of . The gene discussed is DNAI1; the disease is primary ciliary dyskinesia.