Activated NF-κB is known to render the cancer cells resistant to chemotherapy.21, 23 Moreover, CD44, whose transcription is regulated through NF-κB signaling, was discovered to be enriched in a CP-resistant population.33 Therefore, we tested the hypothesis that RAP1 suppresses the sensitivity of NSCLC cells to CP. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.