NOTCH2 and urinary bladder carcinoma: For instance, miR-23b was downregulated in gastric carcinoma and diminished proliferation and metastasis of gastric cancer cells by inhibiting Notch2 expression.19 In bladder cancer, miR-23b was depleted and acted as a tumor-suppressor gene by targeting Zeb1.20 Majid et al.21 also showed that miR-23b repressed Src kinase and inhibit tumorigenesis of prostate cancer.