TGF-β1 is a central regulator of liver fibrosis, and the TGF-β/SMAD signaling pathway is probably the most prominent direct inducer of HSC activation and collagen transcription.28 Smad proteins transduce signals from TGF-β1 to regulate cell proliferation, differentiation, and death. Here, TGFB1 is linked to Hepatic fibrosis.