TGFB1 and pulmonary fibrosis: The downregulation of TGFBR by another miRNA also had antifibrotic effects on the liver39 and pulmonary fibrosis.40 On the basis of these observations, we suggest that the miRNA-mediated diminishment of TGFBR decreases its overall level, which in turn overrides the spatial or temporal regulation of TGF-β/SMAD signaling by different TGFBR regulators.