Multivariate survival analysis showed only the expression of CXCL1 in CAFs was significantly associated with overall survival of ESCC patients treated with chemoradiotherapy, suggesting CXCL1 expressed in CAFs can be used as an independent prognostic factor of ESCC patients treated with chemoradiotherapy (Table 2). The gene discussed is CXCL1; the disease is esophageal squamous cell carcinoma.