As DNA is the main target of ionizing radiation, DNA damage repair is considered as a critical process that determines cell death or survival following radiation.36 Inhibition of DNA damage repair improved the radiosensitivity of several human cancers.37, 38, 39 We further dissected how CAF-secreted CXCL1 enhanced DNA damage repair following radiation in tumor cells. This evidence concerns the gene CXCL1 and neoplasm.