Upon blockage of CAF-secreted CXCL1 signaling by 500 ng/ml CXCL1 antibody or by 400 nM CXCR2 inhibitor SB225002, CAF-enhanced ROS increase following radiation was attenuated in KYSE-30 and in KYSE-150, suggesting CAF-secreted CXCL1 enhanced ROS increase following radiation in tumor cells (Figures 4a and b). The gene discussed is CXCL1; the disease is neoplasm.