When cultured in CAF medium for 24 h, the expression of CXCL1 in KYSE-30 and KYSE-150 showed an increase of 2.8102- and 2.2139-fold, respectively, compared with cultured in normal medium (Figure 1f); CXCL1 was also significantly upregulated in CAF-1 and CAF-2 that were cultured in the conditioned medium (CM) of tumor cells for 24 h, compared with cultured in normal medium (Figure 1f). The gene discussed is CXCL1; the disease is neoplasm.