Aberrant ROS status correlated with several human diseases including cancer, diabetes and aging as ROS was able to activate several cellular signaling pathways involved in DNA damage repair, cell proliferation, differentiation, survival and metabolism, and antioxidant, anti-inflammation response.19 SODs are the chief scavengers of ROS in cells.20 Several studies discovered SODs as important targets to reverse ROS-induced radioresponse.40 Our study uncovered CAF-secreted CXCL1 enhanced radiation-induced ROS increase. This evidence concerns the gene CXCL1 and diabetes mellitus.