In contrast to the antiapoptotic function of decreased miR-101-3p level in tumor cells,31, 38 its downregulation promoted apoptosis in mouse primary cardiac fibroblasts exposed to hypoxia.39 Similarly, miR-101 is downregulated in Dicer-knockout mice and increased apoptosis via elevation of Bim expression.22 Consistent with this finding, our data showed that serum deprivation-induced endothelial apoptosis through downregulation of miR-101-3p, which targets Bim. Here, DICER1 is linked to neoplasm.